THE EFFECTS OF CISPLATIN ON THE EPIPHYSEAL GROWTH-PLATE

: In rabbit models, the inhibition of proteoglycan (PG) biosynthesis in the epiphyseal growth plate of the ribs was observed in the group given cisplatin both in vitro and in vitro. Serum alkaline phosphatase (ALP) and the bone-derived ALP isoenzyme were observed to decrease in the young rabbits given cisplatin. In rat models, the length of the tibias in both the groups given cisplatin was significantly shorter than that of those in the control rats. The results described may thus suggest that the injury of the epiphyseal growth plate and growth retardation possibly occur due to the use of cisplatin.