Preparation and Evaluation of 1,3-Diaminocyclopentane-Linked Dihydropyrimidinone Derivatives as Selective α1a-Receptor Antagonists.

Abstract Several 1,3-diaminocyclopentane linked α 1a -receptor antagonists were prepared using a divergent chemical strategy that allows for rapid analysis of all stereochemical permutations for their effect on α 1 -receptor binding.