Efficacy of Sufentanil during Laryngeal Microscopic Surgery

Background: Various anesthetic agents have been used in laryngeal microscopic surgery, because the airway is shared with the surgeon, there is a short operation duration and intense cardiovascular stimulation occurs during the surgery. Sufentanil is superior than other anesthetic agents in blocking the cardiovascular response to the airway stimulation and a short duration of effects. Methods: Thirty patients undergoing elective laryngeal microscopic surgery were randomized to receive sufentanil 0.125/kg (group 1, n = 10), sufentanil 0.25/kg (group 2, n = 10) or sufentanil 0.5/kg (group 3, n = 10). The bispectral index score, blood pressure, heart rate, recovery time from general anesthesia, the need for additional analgesics and naloxone and the postoperative complications associated with sufentanil were measured. Results: The bispectral index, blood pressure and heart rate were similar in the three groups. Only four patients in group 3 required naloxone (P /kg is an appropriate dose for the rapid recovery and attenuation of the cardiovascular response in laryngeal microscopic surgery.