Interaction of taxol and other anticancer drugs with hydroxypropyl-β-cyclodextrin

Abstract The interaction between 23 anticancer drugs and hydroxypropyl-β-cyclodextrin (HPβCD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. HPβCD formed inclusion complexes with 15 compounds, the complex always being more hydrophilic than the uncomplexed drug. The inclusion forming capacity of drugs differed considerably according to their chemical structure. The intensity of interaction significantly increased with increasing hydrophobicity of the guest molecule, demonstrating the preponderant role of hydrophobic interactions in inclusion complex formation.