Показатели «Оксидант-антиоксидантной» системы у работников предприятия химической промышленности

Aim. To study the indices of “oxidant-antioxidant” system in workers of enterprises of chemical industry. Materials and methods. To assess the status of “oxidant-antioxidant” system, biochemical and cytochemical investigations were carried out in 208 workers of chemical complex. Biochemical examination of antioxidant component included the determination of catalase activity, general antioxidant activity, blood serum retinol and α-tocopherol content, cytochemical investigation detection of mean cytochemical neutrophile myeloperoxidase coefficient. Results. Analysis of the obtained results detected disbalance in the “oxidant-antioxidant” system characterized by excessive accumulation of lipid peroxidation products, activation and depression of enzymatic activity of antioxidant component in workers employed in harmful conditions of labour at chemical enterprises. Dynamic changes in indices depending on the workers’ records of service were shown; developmental peculiarities of metabolic disorders were revealed. Conclusions. These disorders in the system of antioxidant protection are developing under the effect of complex chemical factors.