Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

Duy-Khanh Dang,Eun-Joo Shin,Yunsung Nam,Sungwoo Ryoo,Ji Hoon Jeong,Choon-Gon Jang,Toshitaka Nabeshima,Jau-Shyong Hong,Hyoung Chun Kim

Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

2016

Duy-Khanh Dang
Eun-Joo Shin
Yunsung Nam
Sungwoo Ryoo
Ji Hoon Jeong
Choon-Gon Jang
Toshitaka Nabeshima
Jau-Shyong Hong
Hyoung Chun Kim

Background Activation of NADPH oxidase (PHOX) plays a critical role in mediating dopaminergic neuroinflammation. In the present study, we investigated the role of PHOX in methamphetamine (MA)-induced neurotoxic and inflammatory changes in mice.

Keywords:

Immunology
Microglia
Biology
Methamphetamine
MAPK/ERK pathway
Neuroinflammation
Apocynin
NADPH oxidase
Dopaminergic
Striatum

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