Tetrahydrothienopyridine Derivatives as Novel GPIIb/IIIa Antagonists.
1997
Abstract The tetrahydrothienopyridine derivatives were derived from aminomethylcyclohexylcarboxylic acid as a lead moiety. Evaluation of the antiplatelet activity and receptor binding assay revealed that compound 1(ME3277) was a novel and potent non-peptide and non-amidinophenyl GPIIb/IIIa antagonist.
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