Ruthenium-selenium coordination compound and application thereof in preparing fluorescent probe and antineoplastic medicine

2010 
The invention discloses a ruthenium-selenium coordination compound and a synthesis method and an application thereof. The molecular formula of the coordination compound of the invention is [Ru (phen) 2p-MOPIP] 2+, the chemical name of the coordination compound is 2-phenanthroline-1, 10-phenanthroline diazole ruthenium coordination compound, the structure of the coordination compound is shown as the general formula (I). The ruthenium-selenium coordination compound of the invention can be served as the fluorescent probe for identifying tumour cells and the receptor on a cell membrane, and can enter the cytoplasm and finally be enriched in the cell nucleus region. As the fluorescent probe, the ruthenium-selenium coordination compound of the invention react with the cancer cell for 30min, then fluorescence intensity remarkably increases, and with the extension of time, the fluorescence intensity further increases; however, the coordination compound shows weak fluorescence or no fluorescence in normal cells. Therefore, the ruthenium-selenium coordination compound of the invention can be used for detecting tumour cells and carrying out fluorescence imaging on the living body and can be also used for preparing medicines for preventing or treating cancers.
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