Dual-ResponsiveDual-Drug-Loaded Bioinspired PolydopamineNanospheres as an Efficient Therapeutic Nanoplatform against Drug-ResistantCancer Cells
2020
Multidrug resistance
evoked by overusing pharmaceuticals of poor
water solubility has posed a serious threat to public health, which
urges the development of safe and efficacious therapeutic formulations.
In this study, biomimetic nanospherical polydopamine (PDA) formed
under mild conditions was modified using methoxypolyethylene glycol
amine (m-PEG-NH2) to produce a polydopamine-based
drug delivery platform. As characterized by various physicochemical
methods, the PEGylated PDA with a uniform size distribution showed
superior biocompatibility and efficient load capability for two hydrophobic
anticancer drugs of paclitaxel and phytochemical curcumin, which exhibited
synergistic cytotoxicity and a pH/ROS-responsive release behavior.
Significantly, an enhanced effect of the encapsulated paclitaxel and
curcumin was identified toward the drug-resistant A549/TAX cancer
cells, which was correlated with the improved cellular internalization
of hyperbranched PDA composites and distinctive cell cycle arrest
of loaded drugs. The dual-drug-loaded spherical PDA nanocomposites
hold enormous potential to tackle drug resistance from a chemotherapy
perspective.
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