Dynamic MR imaging of kidneys perfused with EOB-Gd-DTPA
2011
Gandolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is
a hepatobiliary contrast agent for MRI. It was reported that Gd-EOB-DTPA is
useful to detect liver tumors and differentially diagnose benign and
malignant pathologies in the liver. Since Gd-EOB-DTPA partially accumulates
in the hepatocytes and bile via various transporters after intravenous
injection, signal intensity in the liver increases on T1-weighted images. The
signal intensity of the liver after Gd-EOB-DTPA injection depends on the
Gd-EOB-DTPA uptake by hepatocytes and bile excretion. It is known tha the Gd-
EOB-DTPA accumulating in the kidney is excreted to the urine through
glomerular filltration. Because Gd- DTPA is concentrated in the renal tubules
after being filtered at the Bowman’s capsule, and since it is neither
secreted nor reabsorbed the concentrating and diluting function of the renal
tubules can be studied by imaging techniwues. since renal function can be
evaluated with Gd-EOB-DTPA can also be used to evaluate renal function. Eith
the development of MRI equipment and rapid imaging techniques, temporal
resolution had improved greatly. However, no previous study has been carried
out on renal function using Gd- EOB-DTPA dynamic MR study that was correlated
with estimated glomerular filtration rate (eGFR) and stage of chronic kidney
disease (CKD) in the Japan Association of chronic kidney disease initiative.
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