Ovarian Stimulation Using Oral Therapy Protocols for the Ovulatory Patient Undergoing Intrauterine Insemination

The use of clomiphene or letrozole in ovulatory women undergoing intrauterine insemination is more effective than expectant management, natural cycle-IUI, or oral SO-timed intercourse. Clomiphene or letrozole with IUI is modestly effective and relatively inexpensive treatment with demonstrated safety. The risk with the most impact is multiple gestations. Randomized controlled trials comparing all available treatment options for unexplained infertility, in particular, are needed in order to better counsel patients on the success of treatment while taking into account the time, cost, and side effects.