[Electron microscopic studies on the effects of irradiation and mitoxantrone hydrochloride (Novantrone), alone and in combination, on cells of Harding-Passey melanoma in monolayer culture].
1992
: 2 Gy or 4 Gy irradiation of cultured Harding-Passey melanoma cells revealed electronmicroscopically none or little cell damage. 48 hour exposure of cultures to mitoxantrone concentrations of 1 x 10(-8) M or 3.3 x 10(-8) M also exhibited little cell damage. However, combination of these treatments--in comparison with single treatment--resulted in increased cell damage. The present paper describes the extent of Harding-Passey melanoma cell damage following a radiation exposure (2 or 4 Gy) or a mitoxantrone treatment (1 x 10(-8) M or 3 x 10(-8) M) for 48 hours alone or in combination.
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