Inhibition of spontaneous uterine contractions by nitroglycerin

: Nitrates are in use now for more than 100 years for the treatment of coronary heart disease. We were able to demonstrate, that nitroglycerin induces an immediate and highly significant (p < 0.0001) reduction of the spontaneous active uterine strip preparation. The mechanism of the molecular-biologic level (stimulation by NO of cGMP) is explained.