CDDP+5-FU療法が著効を示した転移性有棘細胞癌の1例

A case of metastatic squamous cell carcinoma successfully treated with CDDP and 5-FU is reported. A 70-year-old man noticed a dark-reddish ulcerated nodule of 15×8mm in size on the left lower abdomen in October, 1993. Although the lesion was surgically excised, the left inguinal lymph node swelling appeared in December, 1995. The inguinal lymph nodes were widely resected following 2 courses of PM chemotherapy (5 mg/day of peplomycin sulfate from day 1 to day 6 and 10 mg/day of mitomycin C on day 7). However, the metastatic lesion with 35×42mm in size in the pelvis and bone invasion to left coxa were detected by CT scan in October, 1997.Since radiation therapy (40 Gy) was not effective, CF chemotherapy (80mg/m2/day of cisplatin on day 1 and 500 mg/m2/day of fluorouracil from day 1 to day 5) was performed. The findings of the metastatic lesion in the pelvis and the bone invasion were not shown in CT scan after 6 courses of CF chemotherapy, respectively. These findings suggest that CF chemotherapy may be one of the effective treatments for metastatic squamous cell carcinoma. [Skin Cancer (Japan) 2000; 15: 295-298]