ANALYSIS OF ADAPTIVE CAPABILITIES OF INDIVIDUAL SYSTEMS OF THE ORGANISM UNDER THE INFLUENCE OF ELECTROMAGNETIC FACTOR OF ECOLOGICAL RISK

Aim: To perform a complex analysis of the adaptive capabilities of the jejunal mucosa morphoenzymological parameters under conditions of chronic exposure to electromagnetic impulses. Methods: In an experiment performed on white laboratory male rats aged 4 months we studied changes in the mitotic activity of the jejunum mucosa crypts epithelial cells after 5, 7 and 10 months of exposure to electromagnetic fields (EMF) of electrical discharges with a density of induced currents of 0.37; 0.7; 0.8; 2.7 kA/m2 and the impulse frequency of 50, 100 and 500 per week. Histoenzymological reactions were carried out on cryostat sections. Quantitative cytological evaluation was performed in the epithelium of 20 longitudinal villi from each animal's micropreparation (х400). Paired t-tests were used for analyses of continuous variables. Results. So-called "amplitude-frequency windows" were established, showing no shifts in relation to the indicators of control and indicating possible manifestations of tolerance and/or adaptation of the studied indicators to individual parameters and EMF. For undifferentiated epitheliocytes of the jejunum mucosa, the "window effect" was recorded with EMF with 0.8 kA/m2 and a frequency of 50 and 500 at 7 and 10 month exposure, respectively. At the same time, the highest level of adaptive reactions was recorded 5 months after the exposure to IEM regardless of density of induced currents with a frequency of 50 and 100 impulses per week. Conclusions. Our analysis made it possible to establish morphofunctional associations between the cellular populations of the epithelio-connective tissue complex of the intestinal system of the body, referring to them as a single system that takes part in the regulation of tissue homeostasis, and also reflects the actual levels of manifestation of reactive, dystrophic processes and adaptive capabilities, depending on the effect of the parameters of the electromagnetic factor.