Discovery of GSK1997132B a Novel Centrally Penetrant Benzimidazole PPARγ Partial Agonist.

Optimization of the PPARγ activity and in vivo pharmacokinetics of a non-acidic benzimidazole derivative, identified as starting point for a centrally penetrant PPARγ partial agonist, leads to the identification of title compound (I), a potent and metabolically stable PPARγ partial agonist.