Synthesis and Biological Activity of a Series of 4-Aryl Substituted Benz(b)azepines: Antagonists at the Strychnine-Insensitive Glycine Site.
2010
Abstract A series of 4-arylbenz[b]azepine analogs were prepared and shown to act as antagonists at the strychnine-insensitive glycine receptor. The heteroaryl substituted benz[b]azepine derivative 11 also showed excellent in vivo activity.
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