Синтез и противовирусная активность производных 2-амино-3-этоксикарбонилпиразинов

A series of substituted 2-amino-3-ethoxycarbonylpyrazines containing indole, resorcinol, thiophenol, ethyl cyanoacetate, indandione, and antipyrine moieties were obtained via reactions of nucleophilic substitution of hydrogen in the initial 2-aminopyrazine 1-oxides. Some of the synthesized compounds inhibit the reproduction of measles viruses and exhibit a weak antiviral activity with respect to Marburg virus. However, most of the new substituted pyrazines are not cytotoxic and exhibit no activity against orthopoxviruses and measles viruses.