Dose-dependent pharmacokinetics of α-methyl-p-tyrosine (α-MT) and comparison of catecholamine turnover rates after two doses of α-MT

Groups of rats were injected i.p. with 0.407 or 1.02 mmoles/kg of D, L-α-methyl-p-tyrosine methylester HCl (α-MT). The time-courses forα-MT in plasma and brain were followed together with the endogenous brain dopamine (DA) and noradrenaline (NA) contents.