Controlling the Spatio-temporal Transport of Particles in Fluid-filled Microchambers

The development of microscale devices that autonomously perform multi-step processes is vital to advancing the use of microfluidics in industrial applications. Such advances can potentially be achieved through the use of “chemical pumps” that transduce the energy from inherent catalytic reactions into fluid flow within microchambers, without the need for extraneous external equipment. Using computational modeling, we focus on arrangements of multiple chemical pumps that are formed by anchoring patches of different enzymes onto the floor of a fluid-filled chamber. With the addition of the appropriate reactants, only one of the enzymatic patches is activated and thereby generates fluid flow centered about that patch. These flows drive the self-assembly of microparticles in the solution and localize the particles onto the activated patches. By varying the spatial arrangement of the enzymatic patches, and the sequence in which the appropriate reactants are added to the solution, we realize spatio-temporal con...