Method and apparatus for producing a bio-artificial tissue construct
2011
The tissue construct with viable cells in an extracellular matrix of fibrin is prepared by a special process in which a matrix material and cells by means of a rotational molding process in a mold (1) are formed into a particular hollow tubular body, said method comprising the steps of: (A) introducing cells at least one cell type and / or a fibrinogen preparation by means of an applicator (4) in the rotating hollow mold (1), said applicator (4) during the introduction along the rotational axis is shifted, and wherein step (a) a - or is carried out several times; (B) continuing the rotation operation until solidification of the fibrinogen to form a dimensionally stable matrix to obtain a primarily solidified tissue construct; (C) demolding the tissue construct. The construct can be obtained in a relatively short time, from autologous materials.
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