Development of relationship between bronchial asthma and polymorphisms of interlenkin-4 receptor α chain Q576R gene

Interleukin-4 receptor(IL-4R) plays a key role in the development of bronchial asthma (asthma). IL-4 connects with IL-4R, which in stimulates signal transducer and activator of transcription 6 (STAT6) phosphorylationed to be a dipolymer. This dipolymer goes to nucleolus from cytochylema which induces the transcription of the cytokine of helper T cell 2 ,leading the symptom of asthma. There is a Q576R polymorphism in IL-4Rα chain gene. R576 is related to the susceptivity of asthma,which may be a candidate gene of susceptivity of childhood asthma. IL-4R α chain 576 plays an important role in the serum IgE level. Reports about the relativity between R576 and the total serum IgE level are not the same. The polymorphisms of other genes are also related to asthma, the interaction between gene and gene has been concerned. This report summarizes the development of the relationship between asthma and polymorphisma of IL-4R α chain Q576R gene. Key words: Asthma; Interleukin-4 receptor; Q576R; Signal transducer and activator of transcription 6