АЛЬФА-ФЕТОПРОТЕИН В ПРОГНОЗЕ ВЫЖИВАЕМОСТИ И ФУНКЦИОНАЛЬНОГО ВОССТАНОВЛЕНИЯ БОЛЬНЫХ С ИШЕМИЧЕСКИМ ИНСУЛЬТОМ

The study was carried out to determine the prognostic value of alpha-fetoprotein in development of lethal outcome and degree of functional rehabilitation of patients with ischemic stroke. The sampling included 216 patients in acute period of ischemic stroke. At the fi rst day of development of disease they were measured the level of human alpha-fetoprotein. At the second day of disease patients were evaluated the degree of functional rehabilitation and the rate of lethal outcomes was calculated. Previou sly, the reference interval for alpha-fetoprotein was calculated according the guidelines of the International federation of clinical chemistry and national standard. The reference interval amounted to 0.59-3.78 mE/l. The study results demonstrated that low lev el of alpha-fetoprotein is related to higher risk of lethal outcome (SE=1.7, p=0.012). The increasing of level of alpha-fetoprotein over mentioned threshold value statistically signifi cant increases probability of survival of patients. The further increasing more than 2.28 mE/l is related to subsequent good functional rehabilitation according the modifi es Rankine scale (SE=1.4, p=0.001) and Barthel index (SE=1.49, p<0.001).