Clinical analyses of hepatocellular carcinoma and nasopharyngeal multiple primary cancers

Objective To explore the clinicopathological characteristics, diagnosis, treatment outcomes and survival of hepatocellular carcinoma (HCC) and nasopharyngeal multiple primary cancers. Methods The clinical data of 12 male patients with hepatocellular and nasopharyngeal multiple primary cancers were retrospectively analyzed. Results Second primary cancer was diagnosed with a median age of 54.5 years. Hepatitis B surface antigen (HBsAg) was detected in 7 patients (58.3%) and 6 cases (50.0%) had a family history of cancer. The treatments included radiochemotherapy (n=5), radiotherapy (n=6) and non-therapy (n=1). And the interventions included hepatic surgery (n=6), interventional treatment (n=4) and conservative (n=2). The 1, 3 and 5-year overall survival rates were 90.9%, 81.8% and 58.4% and the HCC-specific survival rates 80.0% at 1 year and 57.1% at 3 years respectively. The HCC-specific survival rates of surgery group were significantly better than those of the non-surgical group. The 1, 3-year HCC-specific survival rates were 100.0%, and 100.0%vs 50.0% and 0 respectively (P=0.002). Conclusions HCC and nasopharyngeal multiple primary cancers are not rare and careful follow-ups are necessary .The co-existence of HCC and nasopharyngeal multiple primary cancers does not imply a worse prognosis. And radical resection of HCC is considered. Key words: Liver neoplasms; Nasopharyngeal neoplasms; Multiple primary carcinoma; Surgery; Prognosis