Tumor Targeting via Sialic Acid: [ 68 Ga]DOTA-en-pba as a New Tool for Molecular Imaging of Cancer with PET

Charalambos Tsoukalas,Simonetta Geninatti Crich,Anastasios Gaitanis,Theodoros Tsotakos,Maria Paravatou-Petsotas,Silvio Aime,Rogelio Jiménez-Juárez,Constantinos Anagnostopoulos,Kristina Djanashvili,Penelope Bouziotis

Tumor Targeting via Sialic Acid: [ 68 Ga]DOTA-en-pba as a New Tool for Molecular Imaging of Cancer with PET

2018

Charalambos Tsoukalas
Simonetta Geninatti Crich
Anastasios Gaitanis
Theodoros Tsotakos
Maria Paravatou-Petsotas
Silvio Aime
Rogelio Jiménez-Juárez
Constantinos Anagnostopoulos
Kristina Djanashvili
Penelope Bouziotis

Purpose The aim of this study was to demonstrate the potential of Ga-68-labeled macrocycle (DOTA-en-pba) conjugated with phenylboronic vector for tumor recognition by positron emission tomography (PET), based on targeting of the overexpressed sialic acid (Sia).

Keywords:

Radiology
Medicine
Cancer
DOTA
Positron emission tomography
Molecular biology
Sialic acid
Molecular imaging
pet imaging
Cancer research
tumor targeting
Nuclear medicine

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