Изучение влияния диазепама на тревожные реакции у мышей, вызванные индометацином

There were the cases to observe the development of anxiety following administration of indomethacin. One mechanism suggested of this side drug effect is indomethacin-induced inhibition of the synthesis of the positive modulator GABA receptors allopregnanolon. In test «open field» for the first time has shown anxiety in male of inbred mice Balb/c administrated with 10 mg/kg of indomethacin. It was observed the decrease of indomethacin-induced anxiety 30 minute after treatment with classic anxiolytic diazepam with single dose of 1 mg/kg intraperitoneally. There was complete elimination of the anxiety response.