Etiological characteristics of urinary tract calculi after holmium laser lithotripsy and the effects of urine related factors research

Objective To investigate the pathogenic characteristics of postoperative infection of ureteral lithiasis with holmium laser lithotripsy and the effects of urine related factors research on ureteral lithotripsy. Methods 490 Cases of ureteral calculi treated in the hospital during January 2013 to 2018 January were selected as the research subjects. Ureteroscopy holmium laser lithotripsy was performed to analyze the incidence of postoperative infection. The pathogenic bacteria of the infected patients were isolated and analyzed, and the changes of C-reactive protein (CRP), procalcitonin (PCT), white blood cells (WBC) and interleukin (IL)-6 in the urine of the infected and uninfected patients were analyzed. Results In 490 patients with ureteral calculi, 51 cases had postoperative infection, and the infection rate was 10.41%.67 strains of pathogenic bacteria were isolated from 51 cases of ureteral lithiasis infection, 39 strains were isolated from Gram-negative bacteria and 58.21% were isolated, followed by Gram-positive bacteria, 26 strains were isolated, accounting for 38.81%. Among the isolates, 15 were Escherichia coli, 10 were Pseudomonas aeruginosa, 10 were Enterococcus and 8 were Staphylococcus aureus. Among the main Gram-negative bacteria, the resistance rate of Escherichia coli to cefoperazone was 80%, and the resistance rate of Pseudomonas aeruginosa to ceftazidime was 80%. Among the main Gram-positive bacteria, the resistance rate of Enterococcus to penicillin was 70%, and the resistance rate of Staphylococcus aureus to penicillin was 75%. The levels of urine CRP, PCT, WBC and IL-6 in the infection group were higher than those in the non infected group (t=67.728, 87.672, 24.726, 30.941, P<0.01). Conclusion The pathogenic bacteria of ureteral lithotripsy are mainly Gram-negative bacteria after holmium laser lithotripsy, and the levels of related factors research in the urine of the infected patients are obviously increased, which are of important reference value for evaluating the infection and should be used for reference. Key words: Ureteral calculi; Holmium laser lithotripsy; Postoperative infection; Etiology; C reactive protein; Procalcitonin; White blood cell count; Interleukin-6