EVALUATION OF THE RISK FACTORS OF COMPLETE MOLAR PREGNANCY

Introduction: Complete molar pregnancy is the most common gestational trophoblastic disease That has different incidence rate in different societies and the evaluation of its related risk factors may reveal the reason for these differences. The purpose of the present study was to evaluate some of the risk factors of complete molar pregnancy. Methods: A case-control study was performed on 91 cases of complete molar pregnancy (case group) and 295 cases of normal term pregnancy (control group) in Akbarabadi hospital in Tehran city (1996-2006). Subjects were selected by simple sampling method. Then the maternal age, parity and gravidity, blood group and Rh, history of molar pregnancy, consanguinity, history of spontaneous abortion, contraception method and race (Afghan or Iranian), were compared in the two groups. Data was analyzed by SPSS 16 software using Chi-square test, fisher’s exact test and logistic regression. Results: History of molar pregnancy OR, CI 95=5.7 (1.2-25.6), spontaneous abortion OR, CI 95=2.1(1.7-2.6), maternal age higher than 35 year OR, CI 95=2.3 (1.3-3.9) and lower than 20 years OR, CI 95=1.6 (1.4-1.9), consanguinity OR, CI 95=1.3 (1.1-1.5), and Iranian race OR, CI 95= 1.9(1.5-2.4) were found to be risk factors for molar pregnancy. Conclusion: History of molar pregnancy, spontaneous abortion, maternal age, consanguinity and race may be risk-factors for molar pregnancy.