Copper-catalyzed enantioselective C–H functionalization of indoles with an axially chiral bipyridine ligand

Using copper complexes with an axially chiral bipyridine ligand C4-ACBP as the catalyst, an enantioselective functionalization of indoles with diazo compounds was developed with up to 95% ee. This protocol paves the way for further applications of these ligands.