The Impact of Neoadjuvant Hormonal Therapy on the Outcome of Laparoscopic Radical Prostatectomy: A Matched Pair Analysis

Purpose: We evaluated the effect of androgen ablation treatment on laparoscopic radical prostatectomy operative and postoperative parameters.Materials and Methods: A total of 50 patients (group 1) on neoadjuvant androgen deprivation, followed by laparoscopic radical prostatectomy, were compared to 50 (group 2) without any treatment who were matched for prostate volume, laparoscopic pelvic lymphadenectomy, nerve sparing procedure, surgical access type and pathological stage. We analyzed operative time, blood loss, intraoperative and postoperative complications, catheter time, procedure difficulty as scored by the surgeon and surgical margin status.Results: There was no significant difference between the neoadjuvant and nonneoadjuvant groups with respect to mean operative time ± SD (228.6 ± 62.9 vs 219.4 ± 65.1 minutes), mean blood loss (667.6.1 ± 217.1 vs 729.8 ± 285.1 ml) and median catheter time (7 vs 7.5 days). We also found no difference related to the complication rate. Ten of 50 prostate dissections ...