Vascular dysfunction in sepsis: effects of the peroxynitrite decomposition catalyst MnTMPyP.

ABSTRACTThe mechanisms contributing to sepsis vascular dysfunction are not well known. We tested the hypothesis that peroxynitrite scavenging ameliorates sepsis-induced macrovascular and microvascular dysfunction. Male Sprague-Dawley rats were killed 48 h after cecal ligation (n = 15) and puncture o