Manganese-Catalyzed Electrochemical Deconstructive Chlorination of Cycloalkanols via Alkoxy Radicals
2019
A manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols has been developed. This
electrochemical method provides access to alkoxy radicals from
alcohols and exhibits a broad substrate scope, with various cyclopropanols and cyclobutanols converted into synthetically
useful β- and γ-chlorinated ketones (40 examples). Furthermore,
the combination of recirculating flow electrochemistry and continuous inline purification was employed to access products on
gram scale.
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