nSupramolecular synthons in 4-chloroanilinium-5-sulfosalicylate monohydrate: In vitro antioxidant and antimicrobial studies

Abstract A binary organic molecular salt hydrate crystal, 4-chloroanilinium-5-sulfosalicylate monohydrate (4CA5SSA) was obtained in 2:2:1 ratio. A proton of SO3H group in 5-sulfosalicylic acid was transferred to nitrogen atom of 4-chloroaniline leading to form primary N-H…O hydrogen bonding in its crystal structure. R22(8) motif is also observed due to homo dimmer synthon of carboxylic acid. Further, the strong N-H…O and O-H…O hydrogen bonding interactions construct the supramolecular architecture whereas weak C-H…O hydrogen bonds play the dominant role in controlling the interactions between layers in 4CA5SSA salt hydrate. The thermal stability of title crystal was determined by TG/DTA thermogravimetric analysis. The in vitro antimicrobial activity of 4CA5SSA crystal was investigated against bacterial and fungal pathogens. The title compound was also evaluated for its in vitro antioxidant susceptibilities through DPPH radical scavenging methods.