The Correlation of Plasma N-terminal Pro-brain Natriuretic Peptide and Non-dialysis Patients with Chronic Kidney Disease Complicated with Heart Failure

Objective To explore the relationship between plasma N-terminal pro-brain natriuretic peptide(NT-proBNP) and chronic kidney disease(CKD) in patients with heart failure without dialysis.Methods There were 132 CKD non-dialysis patients and were divided according to NYHA functional class: Ⅰ level group of 40 patients,Ⅱ grade group of 34 cases,Ⅲ grade group of 30 cases,Ⅳ-level group of 28 cases.Another 40 cases were selected as healthy control group.Determined NT-proBNP levels were by electrochemiluminescence plasma,left ventricular ejection fraction(LVEF) by echocardiographic determination,serum creatinine,urea nitrogen by automatic biochemical analyzer.Results LVEF progressively decreased,NT-proBNP level of incremental,from the healthy control group to the CKD patients with different cardiac function group(Ⅰ to Ⅳ),the groups were statistically significant differences between(all P 0.01).And LVEF of cardiac function in patients with CKD class Ⅰ group was significantly lower than the control group,NT-proBNP was significantly higher than in the healthy control group.LVEF of different NYHA functional class level of cardiac function were significantly decreased and plasma NT-proBNP concentrations were significantly increased with level of increase in cardiac function.Conclusion NT-proBNP level of CKD non-dialysis patients related to heart function,kidney function,NT-proBNP levels can be used as an evaluation of cardiac function in patients with CKD non-dialysis reference classification,worthy to be popularized.