Longitudinal associations of exposures to phenols during childhood and adiposity measurements in young girls

Introduction: We investigated longitudinal associations between phenol exposures and subsequent adiposity measurements in a multi-ethnic cohort of girls. Methods: Data were collected as part of The Breast Cancer and Environment Research Program at three US sites. 1,239 girls, ages 6-8 years, were enrolled 2004-2007. Ten phenols (benzophenone-3, enterolactone (ETL), bisphenol A, three parabens (methyl, ethyl, propyl), 2,5-dichlorophenol (25DCP), triclosan, genistein, daidzein) were measured from urine collected at baseline visits and categorized as tertiles of creatinine-corrected concentrations. Adiposity measurements of body mass index (BMI), waist circumference (WC), and percent body fat (%BF) were collected at baseline and annual visits through 2015. Linear mixed effects regression, adjusted for race, estimated the effect of urinary phenol concentrations on changes in girls’ adiposity measurements from ages 7-15 years (n=1,017). Results: Girls with high ETL had lower BMI, WC, and %BF at baseline compar...