Antioxidant effect of prostaglandin E2 in the liver alcoholic steatosis

The mechanisms of the antioxidant effect of prostaglandin E2 (PGE2) in cases of chronic alcoholic intoxication were studied. It is shown that PGE2 decreases the production of hydroxyl radicals, lipoperoxides, conjugated dienes, malonic dialdehyde, and carbonyl-containing products of lipid peroxidation. In addition, PGE2 normalizes activity of the liver microsomal monooxygenase system components responsible for the free oxygen radical production.