Alteration in Clinical, Hemobiochemical and Oxidative Stress Parameters in Egyptian Cattle Infected with Foot and Mouth Disease (FMD)

The current study was carried out to study alteration in clinical, hemobiochemical and oxidative stress parameters in native cattle infected with foot and mouth disease (FMD). For this purpose twenty native cattle were used , divided into two equal groups: 10 apparently healthy cattle (control group), 10 cattle with FMD .All cattle were exposed to complete physical clinical examination, blood samples were taken..Hematological analysis revealed significant increase in MCV and MCH (p≤0.001); PCV (p≤0.01); while significant decrease in RBCs (p≤0.001) was (p≤0.001) in serum level of calcium, total protein and globulin ; while significant increase in serum phosphorus (p≤0.05) and glucose levels (p≤0.001) were observed. Nitric oxide (NO), Malondialdehyde (MDA) and DNA fragmentation percentage were significantly increased (p≤0.001) in diseased cattle. However significant reduction in total antioxidant capacity (p≤0.001) and albumin as biomarker for antioxidant status were detected. The highest levels of MDA and NO indicate the occurrence of oxidative stress and lipid peroxidation . In conclusions cattle affected with FMDV experienced strong oxidative stress. So antioxidant drugs recommended during treatment of viral diseases as FMD.