Interaction of Ru-4′-(2-pyridyl)- 2,2′:6′,2″-Terpyridine with Diseased HER2 Protein

The development of new approaches to improve screening, diagnosis, prevention and treatment of cancer is an area of intensive research. Breast cancer is one such widespread category of cancer among women which is the world’s second leading cause of cancer death universally. The objective of this study is to analyze the structural stability of different diseased mutants of HER2 protein as well as to find out the inhibitory effects of Ru-terpyridine over mutant HER2 protein. To accomplish the study insight, we have carried out using different computational tools. From our in silico study, we conclude that, after mutation at positions D769H and V777L in HER2 protein, it was proceeded to cancerous growth and it becomes destabilize, followed by the binding performance of the ruthenium terpyridine over mutant HER2 protein shows the inhibitory effect against HER2 protein-targeted breast cancer.