Profound hypomagnesemia and renal magnesium wasting associated with the use of cyclosporine for marrow transplantation

We prospectively studied 41 marrow transplant patients to evaluate the possible association of hypomagnesemia with cyclosporine immunosuppressive therapy. During the 3 months posttransplant the mean nadir serum magnesium level was 1.06±0.16 mEq/L in 24 patients treated with cyclosporine and 1.33±0.13 in 14 patients treated with methotrexate (P