Synthesis and antimycobacterial activity of purine conjugates with (S)-lysine and (S)-ornithine
2019
Novel purin-6-yl, 2-aminopurin-6-yl and N -(purin-6-yl)glycyl derivatives of ( S )-lysine and (S)-ornithine with free α-functional groups, as well as compounds containing N 9 -(2-hydroxy-ethoxy)methyl substituent in the purine core have been synthesized and tested for their inhibitory effect against Mycobacterium tuberculosis strains. Among the synthesized conjugates, one compound exhibiting a significant level of antimycobacterial activity has been found.
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