TOPICAL ANTI-INFLAMMATORY EFFECTS OF AF 2071: A COMPARATIVE STUDY WITH BENDAZAC AND CORTICOSTEROIDS, BOTH ALONE AND ASSOCIATED

Bendazac has anti-inflammatory effects which are different from or complementary to those of corticosteroids; therefore, it has been associated with hydrocortisone or dexamethasone, in the attempt to obtain a dermatological preparation with a wide range of therapeutic applications. Results in laboratory animals were discouraging, in that a diminished activity was observed. On the other hand, bendacort or (pregn-4ene 3, 20 dione 11β, 17α, 21 trihydroxy, 21 ester with acetic acid [(1-phenylmethyl-1H-indazol-3-yl)-oxy], inhibited both types of inflammatory responses which are sensitive either to bendazac or corticosteroids. Moreover, in acetic acid-induced erythema, which is sensitive to both types of drugs, AF 2071 had stronger effects than those produced by bendazac or corticosteroids. Therapeutic and theoretical implications of these results are discussed.