New-Generation DNA Sequencing Technology

Over the past few years,new DNA sequencing platforms,like 454,Solexa,SOLID,Polonator,and HeliScope,have become widely available,reducing the cost of DNA sequencing by two to three orders of magnitude,and enabling the DNA sequencing to be done readily in some of individual laboratories.New DNA sequencing has dramatically accelerated biomedical research by enabling the analysis of genomes,transcriptomes and metabolomes to become inexpensive,routine and widely-used measures.Here,we would review the principles,features,current states and future impacts of the new DNA sequencing techniques. Key words: DNA sequencing; Genomics; Cyclic-array sequencing