Preparation method of water-soluble material in core-shell or core-corona-shell structure

The invention discloses a preparation method of a water-soluble material in a core-shell or core-corona-shell structure, which comprises the following steps: (1) using a water-soluble material or a water-soluble material modified by a modifying material as a core material; (2) carrying out physical reaction or chemical reaction on the core material and a chemical reagent A to obtain a core material modified by the chemical reagent A; (3) reacting the core material modified by the chemical reagent A in the step (2) with a metal-cation-containing water solution or reaction reagent B to obtain awater-soluble material in a core-shell structure; and (4) repeating the step (2) and the step (3) by using the material in a core-shell structure in the step (3) as a core material to obtain the water-soluble material in a core-corona-shell structure. The method has the advantages of simple technique and high core-shell yield, and is applicable to the fields of bioanalysis, medical diagnosis and imaging, environmental science, analytic science and the like.