Novel molecular targets for risk identification: DNA repair enzyme activities
2007
DNA is continuously damaged by environmental agents and by intracellular byproducts of metabolism [1,2]. If left unrepaired, this DNA damage will cause mutations due to miscoding during replication, thereby increasing cancer risk [1,3]. Therefore, DNA repair is expected to be a major mechanism that protects organisms against cancer. Indeed, in several hereditary diseases that cause high predisposition to cancer, the mutated genes associated with the disorder encode defective DNA repair proteins [3].
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