Are prostatic biopsies necessary in men aged ≥80 years?

OBJECTIVE To examine whether prostatic biopsies are necessary in all men aged ≥80 years, as men found to have prostate cancer are frequently treated with a ‘watch and wait’ policy or with hormonal withdrawal alone, and biopsies are associated with a small but significant complication rate. PATIENTS AND METHODS The findings on a digital rectal examination (DRE), the prostate-specific antigen (PSA) level, the biopsy and staging bone scan results for all men aged ≥ 80 years who had prostatic biopsies over a 3-year period were reviewed, together with those in a group of men aged <80 years for comparison. All biopsy samples had been examined in one of three histopathology units, and 33 consultant urological surgeons contributed. RESULTS In all, 210 biopsies from 205 men aged ≥ 80 years were identified, of whom 163 (79%) had biopsy-confirmed prostate cancer. All 29 men with a PSA level of ≥ 100 ng/mL, 98% of 47 with ≥ 50 ng/mL, 97% of 76 with ≥ 30 ng/mL and 92% of 101 with ≥ 20 ng/mL had biopsy cores containing cancer; 63% of men with a PSA level of <20 ng/mL had cancer on biopsy. In men with cancer and a PSA level of ≥ 30 ng/mL, 92% had Gleason grade ≥ 7 and 93% were treated with hormonal withdrawal alone. In all men with cancer the DRE was abnormal in 91%, the mean number of positive cores was 59% and the bone scan was positive in 18%. The DRE was abnormal in 77% of men with benign biopsies. CONCLUSIONS In men aged ≥ 80 years with a PSA level of ≥ 30 ng/mL, at least 97% had prostate cancer, >90% of whom had high-grade disease, and nearly all with cancer received active pharmacological treatment. In the vast majority of these men prostate biopsies did not alter their cancer management. The value of prostatic biopsy in this age group, with a PSA level of ≥ 30 ng/mL, is questionable.