Hydrodynamic and Species Transfer Simulations in the USP 4 Dissolution Apparatus: Considerations for Dissolution in a Low Velocity Pulsing Flow

Deirdre M. D’Arcy,Bo Liu,Geoff Bradley,Anne Marie Healy,Owen I. Corrigan

Hydrodynamic and Species Transfer Simulations in the USP 4 Dissolution Apparatus: Considerations for Dissolution in a Low Velocity Pulsing Flow

2010

Deirdre M. D’Arcy
Bo Liu
Geoff Bradley
Anne Marie Healy
Owen I. Corrigan

Purpose To simulate the hydrodynamics in the flow-through (USP 4) dissolution apparatus and investigate the effects of hydrodynamics on mass transfer in a low velocity pulsing flow.

Keywords:

Volumetric flow rate
Dissolution
Boundary layer
Natural convection
Dissolution testing
Flow visualization
Chemistry
Chromatography
Mass transfer
pharmaceutical technology
pharmacology toxicology
Flow (psychology)
Mechanics

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