Preparation method of artificial phospholipid DSPG

The invention provides a preparation method of artificial phospholipid DSPG. The preparation method comprises the following steps: oxidizing 3-halogenated propylene serving as a raw material so as to obtain (S)-1, 2-diol-3-halogenated propane, then carrying out addition reaction between (S)-1, 2-diol-3-halogenated propane and stearic anhydride or stearoyl halide, introducing phosphate groups with protecting groups, and removing the protecting groups so as to obtain (R)-1, 2-glycerin distearate-glycerin-3-phosphatidic acid; finally carrying out addition reaction between (R)-1, 2-glycerin distearate-glycerin-3-phosphatidic acid and 2, 2-dimentyl-4-methyl alcohol-1, 3-dioxolame in anhydrous pyridine so as to obtain (R)-1, 2-distearoyl phosphatidyl glycerol. The preparation method is simple in steps, mild in reaction and suitable for industrial production.