Styrylquinazoline derivatives as HIV-1 integrase inhibitors.
2002
Styrylquinazoline derivatives were prepared by Perkin condensation and evaluated for inhibitory activity against HIV-1 integrase. Among them, compound 5 containing a free catechol ring was the most potent (IC 50 = 20.8 ± 1.9 μM) and showed 6-fold more potency than the corresponding styrylquinoline compound (IC 50 = 130.7 ± 8.6 μM).
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