Flavonol and secoiridoid glycosides from Coutoubea spicata

Abstract Two flavonol glycosides, unusual for the Gentianaceae, clovin and the new quercetin 3- O -rhamnosyl-(1 → 6)-(4″- trans-p -coumaroyl)galactoside 7- O -rhamnoside (4″- trans-p -coumaroylclovin) have been isolated from the aerial parts of Coutoubea spicata . The bitter principles of C. spicata were identified as gentiopicrin and swertiamarin. Minor polyphenolic glycosides were characterized by high pressure liquid chromatography with photodiode array detection (HPLC-UV/Vis).