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Synthesis method of R-salmeterol

2016 
The invention provides a synthesis method of R-salmeterol (V). The synthesis method comprises the following steps that a compound (I) and N-benzyl-6-(4-phenyl butoxy)-1-hexylamine take a reaction to obtain a compound (II); the compound (II) is hydrolyzed under the acidic condition to obtain a compound (III); the compound (III) is subjected to asymmetric reduction to obtain a compound (IV); the compound (IV) is subjected to deprotection to obtain the R-salmeterol (V). The route is simple; the target product of R-salmeterol (V) is obtained by using 2-acetoxyl group-5-(2-bromoacetyl) phenmethyl acetic ester and the N-benzyl-6-(4-phenyl butoxy)-1-hexylamine as raw materials through total four steps of reaction. The synthesis method has the advantages that the reaction conditions are mild; the operation is simple and convenient; the yield is high; the stereoselectivity is good; the production cost is low; the synthesis method is suitable for industrial production; great practical application values and social economical benefits are realized. The structural formula is shown as the accompanying drawing.
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